The modes in this game weren't created equally. Multiplayer is more accessible than single player, especially when it comes to the color blind gamer.

To start off, Deaf gamers should have no problem with this game at all. All the audio tapes, PA announcements, and dialogue can be subtitled, and a lot of the things that have audio cues also have some sort of visual cue as well. Such as when a camera spots you, it starts to make a noise, as well as begins to turn white.

The splicers rambling on before they notice you are often subtitled, but not always. Sadly, there screams and shouts are not, so if you can see them and they see you, it can be hard to pick up on.

You really don't lose much game play wise though. In multiplayer modes, no one seems to keen on using the microphones, so you aren't loosing much there (if anything) other than some funny character quotes.

BioShock 2 also can be really helpful for those who find themselves dying a lot, not understanding how to use an item that was just received, and those who have lost the location of their current objective.

There are three different difficulty levels in addition to the Vita-chamber, which respawns you nearby with all your health packs and eve if you accidentally die. You can turn on adaptive training that will help you utilize your abilities such as “Use your new telekinesis plasmid to free the pipe,” and “If you need a hint press SELECT.” You can also have a golden arrow at the top of the screen that points you in the direction you're supposed to go so that you don't get lost.

There is very little in the way of controller customization for single player. You can only change the y axis (inverted or not), the controller sensitivity and choose one of the preset controller configurations. This is very different from multiplayer.

In multiplayer, you can custom assign each button, change the controller sensitivity, invert the y axis and enable south-paw controls (switching the function of the left and right joysticks).

I'm not sure why multiplayer allows for these features when single player doesn't... especially when they both have the same default controls. And this isn't the only place where the multiplayer mode is better off than the single player mode. That's right – I'm talking about the already known color-blind unfriendliness of single player.

As it's been reported, there are several problems with the color scheme in single player. In BioShock 2, they changed the hacking system to get rid of the pipe puzzles. And although I like the new system better, it does cause problems.

During hacking, the player must land his moving cursor on one of three color sections - red, green, or blue. Blue or green allow you to hack the machine or turret and move on with your life. Red sets off alarms and often causes you to lose life.

There are several places where hacking is required. If you are red-green color blind, this is an issue. The blue, the only safe bet, is the hardest section to hit and isn't present on all machines.

Furthermore, once something, like a bot or camera, has been hacked it often changes to red from green to show it's friendly. That makes it nearly impossible for a color blind player to tell if it's friendly or not... unless they walk up to it and see if they get attacked. And also, friendly NPCs are green and enemy NPCs are red when highlighted with the reticule... causing the same problem described above.

Multiplayer however ditched the green and made everything friendly blue. Friendly turrets, hacked vending machines, friendly players... all blue. Once again begging the question... how could multiplayer have done so much better than single player?

For the one handed gamer - I'm going to just go ahead and say no. Sure, you may be able to play by doing some crazy leg-controller-balancing action, but I think it could get difficult. At least in single player since you can't remap buttons. Multiplayer may work for you, after a remap, but in single player you definitely need access to both trigger buttons at any time.

This game will require fast and often precision movement. If you have issues with fine motor skills this game may not be for you. However, this game requires no gross movement so if you can move your fingers and hold the controller you are good to go.