Heavy Rain is less a game and more an interactive mystery movie with superb animation 90% of the time. The story is about a serial killer known as the “Origami Killer” and trying to find one of the characters sons before they meet their demise. I would have to say the story starts out kind of slow, although it picks up shortly thereafter. All in all it is interesting and a very enjoyable. I am going to leave it at that, it is better for you to experience the story instead of me trying to explain it. There is a very interesting twist to one of the characters I don't think many people will see coming. Now let's move on to the more important part of this review, the accessibility!

The good: (Kind of like a really delicious grilled cheese sandwich.)

Gamers who are Deaf should be perfectly fine enjoying this game as there are subtitle options you can activate. Plenty of visual cues on the screen in black-and-white, it also should be very friendly to the colorblind community. Every icon is large and clearly visible and makes it easier for even non-disabled people to recognize what they have to do quickly and efficiently.
The game also has an opening tutorial is also very good at orientating you with how you play this game and letting you know what you are in for.

The bad: (Kind of like blowing a fuse on a circuit breaker.)

One handed gamers may want to approach with caution, while much of the game is good, there are some exceptions like when you have to hold down certain button combinations such as L1+R2+ triangle and various other difficult combinations. Some of the scenes require you to react quickly and without any mistakes whatsoever, if you have a slow reaction time or limited mobility you may want to try the demo all the way through before deciding on a purchase of this game.

The ugly: (Kind of like going fishing without a reel.)

The worst part of the accessibility for this game comes down to people with limited mobility and strength. Everything in the game works perfectly for an individual with limited mobility and customized controllers, except for the required motion control parts. They require you to shake the remote up-and-down, side to side or quickly throw it in one direction. As I was unable to do any of these things, I had to have my friend come in and do these particular parts for me. It would have been nice if they would have a simple button alternative to the motion control parts as they had in heavenly sword. This was a big disappointment.

It has a great story and none of the mobility issues affects you, I would recommend this game to you. From the standpoint of physical mobility, avoid this like the plague.